nmr based metabonomics study on celiac disease in the blood serum
نویسندگان
چکیده
normal 0 false false false en-us x-none fa microsoftinternetexplorer4 aim : the aim of this study is to look for the proper methods that would be a major step towards untreated cd diagnosis and seek the metabolic biomarkers causes of cd and compare them to control group. background : celiac disease (cd) is a common autoimmune disorder that is not easily diagnosed using the clinical tests. patients and methods : thirty cases and 30 controls were entered into this study. metabolic profiling was obtained using proton nuclear magnetic resonance spectroscopy ( 1 hnmr) to seek metabolites that are helpful for the detection of cd. classification of cd and healthy subject was done using random forest (rf). results : the obtained classification model showed an 89% correct classification of cd and healthy subject for the external test set. the metabolites that caused changes in people with cd were identified using rf; these metabolites include lactate, valine and lipid. conclusion : the findings of the present study reveal serum lactate, valin and lipid levels in cd patient are lower than healthy cohorts . this metabolite may provide diagnostic tools as well as insight into potential targets for disease therapy.
منابع مشابه
NMR based metabonomics study on celiac disease in the blood serum
AIM The aim of this study is to look for the proper methods that would be a major step towards untreated CD diagnosis and seek the metabolic biomarkers causes of CD and compare them to control group. BACKGROUND Celiac disease (CD) is a common autoimmune disorder that is not easily diagnosed using the clinical tests. PATIENTS AND METHODS Thirty cases and 30 controls were entered into this st...
متن کاملRole of NMR metabonomics in Celiac Disease (CeD)
Metabonomics study provides a comprehensive metabolic profile of biological samples using techniques like mass spectroscopy and nuclear magnetic resonance (NMR) spectroscopy. The metabolites identified are later analysed using multivariate statistical methods. Metabonomics has the potential to provide putative biomarker/s for disease diagnosis and for monitoring the disease progression and can ...
متن کاملA Metabonomics Study on Celiac Disease by CART
Celiac disease (CD) is an immune reaction as a consequence of ingestion of gluten. Diagnosis of CD is not easily using the clinical tests. Then, the discovery of appropriate methods for CD diagnosis is necessary. This study was concentrated to seek the metabolic biomarkers causes of CD compare to healthy subjects.In the present study, we classify CD and healthy subjects using classification and...
متن کاملmetabonomics based nmr in crohn’s disease applying pls-da
aim : the aim of this study was to search for metabolic biomarkers of crohn’s disease (cd). background : crohn's disease (cd) is a type of inflammatory bowel disease that causing a wide variety of symptoms. cd can influence any part of the gastrointestinal tract from mouth to anus. cd is not easily diagnosed because monitoring tools are currently insufficient. thus, the discovery of proper meth...
متن کاملMetabonomics based NMR in Crohn's disease applying PLS-DA
AIM The aim of this study was to search for metabolic biomarkers of Crohn's disease (CD). BACKGROUND Crohn's disease (CD) is a type of inflammatory bowel disease that causing a wide variety of symptoms. CD can influence any part of the gastrointestinal tract from mouth to anus. CD is not easily diagnosed because monitoring tools are currently insufficient. Thus, the discovery of proper method...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
gastroenterology and hepatology from bed to benchجلد ۶، شماره ۴، صفحات ۲۰۱۳-۶
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023